Spitzoid Melanoma ICD-10: C43.9

Skin cancer

Often searched as: mole that changed shape, small bump on skin, weird pink mole, lump on skin that grew, skin cancer symptoms, mole that bleeds, new dark spot on skin, bump on leg or arm…

Clinical urgency level

lowmediumhigh

Systems Affected

skinlymph nodesdistant organs (in advanced metastatic stage)

Severity Levels

mild

Thin lesion (Breslow thickness <1 mm), no ulceration, low mitotic rate — excellent prognosis with surgical excision.

moderate

Intermediate thickness (1–4 mm), possible ulceration, may require sentinel lymph node biopsy.

severe

Thick lesion (>4 mm), ulceration, lymph node involvement, or distant metastasis — requires multidisciplinary oncologic management.

Red Flags

  • Rapidly growing or changing lesion
  • Nodule larger than 1 cm
  • Ulceration or bleeding from the lesion
  • Color change (darkening, new pink/red tones)
  • Satellite lesions appearing near original spot
  • Enlarged lymph nodes near the affected area

Clinical Presentation

Clinical appearance of a spitzoid melanoma nodule on the leg

View gallery on DermNet NZ (image gallery reference)

When to See a Doctor

Any new, changing, or non-healing lesion — especially a pink, red, or dark papule on the arms, legs, or face — should be evaluated by a dermatologist promptly. Do not wait. Spitzoid melanoma often lacks the classic ABCDE warning signs of typical melanoma, making professional assessment essential.

Differential Diagnosis

  • Spitz nevus (benign — primary diagnostic challenge)
  • Atypical Spitz tumor (STUMP — uncertain malignant potential)
  • Pyogenic granuloma
  • Hemangioma
  • Basal cell carcinoma (amelanotic variant)
  • Nodular melanoma
  • Xanthogranuloma

Comorbidities

  • Familial atypical multiple mole-melanoma (FAMMM) syndrome
  • Personal or family history of melanoma
  • Dysplastic nevus syndrome
  • Xeroderma pigmentosum (rare, genetic)

Prognosis

When diagnosed early (thin lesion, localized), the prognosis is excellent — 5-year survival exceeds 95%. In children, outcomes tend to be more favorable than in adults even with lymph node involvement. With deeper lesions or distant metastasis, prognosis worsens significantly. Molecular testing (FISH, CGH) helps clarify diagnosis and guide treatment planning.

Detailed Overview

Causes, Symptoms, and When to Take Action Spitzoid melanoma is a rare type of skin cancer that can resemble a harmless mole. It often appears as a small, uniform spot, which can make early recognition more difficult. How It Looks Texture: A raised bump or papule, sometimes smooth and even in surface Color: Pink, reddish, skin-colored, or dark brown to black Shape: Round or oval, often symmetric in early stages Location: Common on the arms, legs, or face, but may appear anywhere on the body Why Does It Appear? Develops when pigment-producing cells (melanocytes) in the skin mutate and begin to grow uncontrollably Ultraviolet (UV) exposure from sunlight or tanning beds increases risk Genetic predisposition and DNA repair defects may also play a role Should You Be Concerned? Yes. Although spitzoid melanoma can look benign, it is a malignant tumor and requires prompt evaluation. It may resemble a regular mole, leading to delayed diagnosis The earlier it is detected and treated, the better the outcome Any new, changing, bleeding, or non-healing lesion should be examined by a dermatologist Can You Prevent It? Protect skin from UV exposure by using sunscreen and wearing protective clothing Avoid tanning beds Perform regular skin checks and consult a dermatologist about new or evolving spots 👉 How Piel AI Can Help Piel AI can help you track any mole or lesion over time using photos. While it cannot diagnose, it supports early detection by showing visible changes that should be evaluated by a professional. Summary Spitzoid melanoma is a form of skin cancer that can mimic a benign mole. It often presents as a small, symmetric, or pink bump. The main risk factors include UV exposure and genetics. Early detection through regular monitoring is essential for the best outcome.

Tags

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