Spitzoid Melanoma ICD-10: C43.9
Often searched as: mole that changed shape, small bump on skin, weird pink mole, lump on skin that grew, skin cancer symptoms, mole that bleeds, new dark spot on skin, bump on leg or arm…
Clinical urgency level
Systems Affected
Severity Levels
mild
Thin lesion (Breslow thickness <1 mm), no ulceration, low mitotic rate — excellent prognosis with surgical excision.
moderate
Intermediate thickness (1–4 mm), possible ulceration, may require sentinel lymph node biopsy.
severe
Thick lesion (>4 mm), ulceration, lymph node involvement, or distant metastasis — requires multidisciplinary oncologic management.
Red Flags
- Rapidly growing or changing lesion
- Nodule larger than 1 cm
- Ulceration or bleeding from the lesion
- Color change (darkening, new pink/red tones)
- Satellite lesions appearing near original spot
- Enlarged lymph nodes near the affected area
Clinical Presentation
Clinical appearance of a spitzoid melanoma nodule on the leg
View gallery on DermNet NZ (image gallery reference)Histopathology of spitzoid melanoma
View gallery on Wikimedia Commons (histology category)When to See a Doctor
Any new, changing, or non-healing lesion — especially a pink, red, or dark papule on the arms, legs, or face — should be evaluated by a dermatologist promptly. Do not wait. Spitzoid melanoma often lacks the classic ABCDE warning signs of typical melanoma, making professional assessment essential.
Differential Diagnosis
- Spitz nevus (benign — primary diagnostic challenge)
- Atypical Spitz tumor (STUMP — uncertain malignant potential)
- Pyogenic granuloma
- Hemangioma
- Basal cell carcinoma (amelanotic variant)
- Nodular melanoma
- Xanthogranuloma
Comorbidities
- Familial atypical multiple mole-melanoma (FAMMM) syndrome
- Personal or family history of melanoma
- Dysplastic nevus syndrome
- Xeroderma pigmentosum (rare, genetic)
Prognosis
When diagnosed early (thin lesion, localized), the prognosis is excellent — 5-year survival exceeds 95%. In children, outcomes tend to be more favorable than in adults even with lymph node involvement. With deeper lesions or distant metastasis, prognosis worsens significantly. Molecular testing (FISH, CGH) helps clarify diagnosis and guide treatment planning.
Detailed Overview
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